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Significance of DNA polymerase I in in vivo processing of clustered DNA damage

Abstract:

We examined the biological consequences of bi-stranded clustered damage sites, consisting of a combination of DNA lesions, such as a 1-nucleotide gap (GAP), an apurinic/apyrimidinic (AP) site, and an 8-oxo-7,8-dihydroguanine (8-oxoG), using a bacterial plasmid-based assay. Following transformation with the plasmid containing bi-stranded clustered damage sites into the wild type strain of Escherichia coli, transformation frequencies were significantly lower for the bi-stranded clustered GAP/AP...

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Journal:
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume:
749
Issue:
1-2
Pages:
9-15
Publication date:
2013-09-01
DOI:
EISSN:
0921-8262
ISSN:
0027-5107
Source identifiers:
432650
Language:
English
Keywords:
Pubs id:
pubs:432650
UUID:
uuid:6638c665-2c88-4965-b01f-52dd5ec8304b
Local pid:
pubs:432650
Deposit date:
2013-12-11

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