- Abstract:
-
We examined the biological consequences of bi-stranded clustered damage sites, consisting of a combination of DNA lesions, such as a 1-nucleotide gap (GAP), an apurinic/apyrimidinic (AP) site, and an 8-oxo-7,8-dihydroguanine (8-oxoG), using a bacterial plasmid-based assay. Following transformation with the plasmid containing bi-stranded clustered damage sites into the wild type strain of Escherichia coli, transformation frequencies were significantly lower for the bi-stranded clustered GAP/AP...
Expand abstract - Publisher copy:
- 10.1016/j.mrfmmm.2013.07.010
-
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- Journal:
- Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
- Volume:
- 749
- Issue:
- 1-2
- Pages:
- 9-15
- Publication date:
- 2013-09-05
- DOI:
- EISSN:
-
0921-8262
- ISSN:
-
0027-5107
- URN:
-
uuid:6638c665-2c88-4965-b01f-52dd5ec8304b
- Source identifiers:
-
432650
- Local pid:
- pubs:432650
- Language:
- English
- Keywords:
- Copyright date:
- 2013
Journal article
Significance of DNA polymerase I in in vivo processing of clustered DNA damage
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