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Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease.

Abstract:

Macroautophagy, a major pathway for organelle and protein turnover, has been implicated in the neurodegeneration of Alzheimer's disease (AD). The basis for the profuse accumulation of autophagic vacuoles (AVs) in affected neurons of the AD brain, however, is unknown. In this study, we show that constitutive macroautophagy in primary cortical neurons is highly efficient, because newly formed autophagosomes are rapidly cleared by fusion with lysosomes, accounting for their scarcity in the healt...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Role:
Author
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Journal:
The Journal of neuroscience : the official journal of the Society for Neuroscience
Volume:
28
Issue:
27
Pages:
6926-6937
Publication date:
2008-07-05
DOI:
EISSN:
1529-2401
ISSN:
0270-6474
URN:
uuid:660aef60-8764-4bb6-8475-eaf052fb6b26
Source identifiers:
133725
Local pid:
pubs:133725

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