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Thesis

Synthesis of deuterated phosphatidylinositol phosphates

Abstract:

Phosphatidylinositol phosphates (PtdInsPn) are intracellular signalling molecules that are important in many key biological processes, in particular Ca2+ signalling pathways. Dysfunction of these processes has been implicated in numerous diseases including diabetes and many cancers. Some aspects of PtdInsPn signalling have been heavily investigated; PTEN, PKC/Akt, PtdIns3K and PtdIns4K are all important therapeutic targets that have seen much attention in i...

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Department:
Doctoral Training (MPLS)
Role:
Author

Contributors

Department:
Organic Chemistry
Role:
Supervisor
Department:
AstraZeneca
Role:
Supervisor
Department:
Organic Chemistry
Role:
Examiner
Department:
University of Bath
Role:
Examiner
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Funding agency for:
Alex Saunders
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
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Subjects:

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