Increased sensitivity to the effects of chronic social defeat stress in an innately anxious mouse strain.

Journal article

Stress and genetic predisposition are two of the major risk factors for a variety of psychiatric illnesses. Inbred mouse strains are considered useful tools in dissecting the genetic basis of complex disorders. Indeed, mice of the C57BL/6 and BALB/c strains, differing markedly in anxiety behaviours, are among the most widely used in psychopharmacological research. However, there is a paucity of studies investigating the impact of social stress in these two strains. Moreover, whether these two...

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Authors: Savignac, H; Finger, B; Pizzo, R; O'Leary, O; Dinan, T

• Publication status: Published
• Journal: Neuroscience
• Volume: 192
• Pages: 524-536
• Publication date: 2011-09-01
• DOI: 10.1016/j.neuroscience.2011.04.054
• EISSN: 1873-7544
• ISSN: 0306-4522
• Language: English
• Keywords: Mice; Animals; Mice, Inbred BALB C; Social Behavior; Mice, Inbred C57BL; Genetic Predisposition to Disease; Male; Anxiety; Stress, Psychological