Digital intervention (Renewed) to support symptom management, wellbeing, and quality of life among cancer survivors in primary care: a randomised controlled trial

Little, P; Bradbury, K; Stuart, B; Barnett, J; Krusche, A; Steele, M; Heber, E; Easton, S; Smith, KA; Slodkowska-Barabasz, J; Payne, L; Corbett, T; Yao, G; Pollet, S; Smith, J; Joseph, J; Lawrence, M; Bohning, D; Cheetham-Blake, T; Eccles, D; Foster, C; Geraghty, AWA; Leydon, G; Muller, A; Neal, R; Wilde, L

Women's Health Collection

Journal article

Digital intervention (Renewed) to support symptom management, wellbeing, and quality of life among cancer survivors in primary care: a randomised controlled trial

Abstract:: Background: many cancer survivors following primary treatment have prolonged poor quality of life.Aim: to determine the effectiveness of a bespoke digital intervention to support cancer survivors.Design: Pragmatic parallel open randomised trial.Setting: UK general practices.Methods: people having finished primary treatment (<= 10 years previously) for colo-rectal, breast or prostate cancers, with European-Organization-for-Research-and-Treatment-of-Cancer QLQ-C30 score <85, were randomised by online software to: 1)detailed 'generic' digital NHS support ('LiveWell';n=906), 2) a bespoke complex digital intervention ('Renewed';n=903) addressing symptom management, physical activity, diet, weight loss, distress, or 3) 'Renewed-with-support' (n=903): 'Renewed' with additional brief email and telephone support.Results: mixed linear regression provided estimates of the differences between each intervention group and generic advice: at 6 months (primary time point: n's respectively 806;749;705) all groups improved, with no significant between-group differences for EORTC QLQ-C30, but global health improved more in both intervention groups. By 12 months there were: small improvements in EORTC QLQ-C30 for Renewed-with-support (versus generic advice: 1.42, 95% CIs 0.33-2.51); both groups improved global health (12 months: renewed: 3.06, 1.39-4.74; renewed-with-support: 2.78, 1.08-4.48), dyspnoea, constipation, and enablement, and lower NHS costs (generic advice £265: in comparison respectively £141 (153-128) and £77 (90-65) lower); and for Renewed-with-support improvement in several other symptom subscales. No harms were identified.Conclusion: cancer survivors quality of life improved with detailed generic online support. Robustly developed bespoke digital support provides limited additional short term benefit, but additional longer term improvement in global health enablement and symptom management, with substantially lower NHS costs.

Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Little, P., Bradbury, K., Stuart, B., Barnett, J., Krusche, A., Steele, M., Heber, E., Easton, S., Smith, K. A., Slodkowska-Barabasz, J., Payne, L., Corbett, T., Yao, G., Pollet, S., Smith, J., Joseph, J., Lawrence, M., Bohning, D., Cheetham-Blake, T., … Wilde, L. (2023). Digital intervention (Renewed) to support symptom management, wellbeing, and quality of life among cancer survivors in primary care: a randomised controlled trial. British Journal of General Practice, 75(754), e357–e365.

MLA Style

Little, P, et al. “Digital Intervention (Renewed) to Support Symptom Management, Wellbeing, and Quality of Life among Cancer Survivors in Primary Care: a Randomised Controlled Trial.” British Journal of General Practice, vol. 75, no. 754, 2023, pp. e357–e365.

Chicago Style

Little, P, K Bradbury, B Stuart, et al. 2023. “Digital Intervention (Renewed) to Support Symptom Management, Wellbeing, and Quality of Life among Cancer Survivors in Primary Care: a Randomised Controlled Trial.” British Journal of General Practice 75 (754): e357–e365.
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