Journal article
The aorta can act as a site of naıve CD41 T-cell priming
- Abstract:
-
Aims - Aortic adaptive immunity plays a crucial role in atherosclerosis; however, the precise mechanisms leading to T cell activation in the arterial wall remain poorly understood. Methods and Results - Here we have identified naïve T cells in the aorta of wild-type and TCR transgenic mice and we demonstrate that naïve T cells can be primed directly in the vessel wall with a similar activation profile to splenic and lymphoid T cells. Aortic homing of naïve T cells is regulated at least in pa...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Wellcome Trust
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Bibliographic Details
- Publisher:
- Oxford University Press Publisher's website
- Journal:
- Cardiovascular Research Journal website
- Article number:
- cvz102
- Publication date:
- 2019-04-13
- Acceptance date:
- 2019-04-09
- DOI:
- ISSN:
-
1755-3245
Item Description
- Keywords:
- Pubs id:
-
pubs:987700
- UUID:
-
uuid:65d2f6f8-00b0-4a01-ace8-cd5cd6b424b2
- Local pid:
- pubs:987700
- Source identifiers:
-
987700
- Deposit date:
- 2019-04-08
Terms of use
- Copyright holder:
- MacRitchie et al
- Copyright date:
- 2019
- Notes:
- © The Author(s) 2019. Published by Oxford University Press on behalf of the European Society of Cardiology. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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