Journal article
LnDOTA releasing probes for luminescence and magnetic resonance imaging
- Abstract:
- Lanthanide complexes of DOTA monoesters bearing nitrobenzyl and nitroimidazole groups are shown to be converted to the corresponding DOTA complexes under chemical and enzymatic conditions, giving rise to favorable changes in the luminescence properties of the europium and terbium complexes and relaxometric properties of the gadolinium complexes. The nitroimidazole complexes are converted more rapidly than their nitrobenzyl and benzyl analogues. We propose that activation of these complexes may occur by ester cleavage rather than nitro reduction and fragmentation since complexes bearing a simple benzyl group may also be cleaved under the same conditions, albeit more slowly.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 2.7MB, Terms of use)
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- Publisher copy:
- 10.1021/acs.inorgchem.5c00199
Authors
+ Engineering and Physical Sciences Research Council
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- Funder identifier:
- https://ror.org/0439y7842
- Grant:
- EP/S019901/1
- Publisher:
- American Chemical Society
- Journal:
- Inorganic Chemistry More from this journal
- Volume:
- 64
- Issue:
- 13
- Pages:
- 6640–6647
- Publication date:
- 2025-03-24
- Acceptance date:
- 2025-03-06
- DOI:
- EISSN:
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1520-510X
- ISSN:
-
0020-1669
- Language:
-
English
- Pubs id:
-
2100911
- Local pid:
-
pubs:2100911
- Deposit date:
-
2025-03-28
- ARK identifier:
Terms of use
- Copyright holder:
- Foster et al
- Copyright date:
- 2025
- Rights statement:
- © 2025 The Authors. Published by American Chemical Society. This publication is licensed under CC-BY 4.0 .
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