Safety and effectiveness of coronary intravascular lithotripsy in eccentric calcified coronary lesions: a patient-level pooled analysis from the Disrupt CAD I and CAD II Studies

Journal article

Intravascular lithotripsy (IVL) is a novel approach to lesion preparation of severely calcified plaques in coronary and peripheral vessels. Lithotripsy is delivered by vaporising fluid to create an expanding bubble that generates sonic pressure waves that interact with arterial calcification. Available data indicate that IVL leads to increased vessel compliance before stent implantation with high efficacy and an excellent safety profile. Since it gained the CE mark in 2017, and with improved operator experience, the use of IVL has expanded into more complex clinical situations. This review focuses on the best practice for IVL use in the cath lab, based on 3 years of experience with the technology and the latest scientific data from the Disrupt CAD clinical trials

Authors: Blachutzik, F; Honton, B; Escaned, J; Hill, JM; Werner, N

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Springer
• Journal: Clinical Research in Cardiology
• Volume: 110
• Issue: 2
• Pages: 228-236
• Publication date: 2020-09-18
• DOI: 10.1007/s00392-020-01737-3
• EISSN: 1861-0692
• ISSN: 1861-0684
• Language: English
• Keywords: Eccentric; CAD; Medicine; Coronary artery disease; Radiology; Internal medicine; Cardiology