Cytoplasmic RNA: a case of the tail wagging the dog.

Journal article

The addition of poly(A) tails to eukaryotic nuclear mRNAs promotes their stability, export to the cytoplasm and translation. Subsequently, the balance between exonucleolytic deadenylation and selective re-establishment of translation-competent poly(A) tails by cytoplasmic poly(A) polymerases is essential for the appropriate regulation of gene expression from oocytes to neurons. In recent years, surprising roles for cytoplasmic poly(A) polymerase-related enzymes that add uridylyl, rather than ...

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Authors: Norbury, C

• Publication status: Published
• Journal: Nature reviews. Molecular cell biology
• Volume: 14
• Issue: 10
• Pages: 643-653
• Publication date: 2013-10-01
• DOI: 10.1038/nrm3645
• EISSN: 1471-0080
• ISSN: 1471-0072
• Language: English
• Keywords: Polyadenylation; RNA Stability; RNA; RNA, Messenger; Nucleotidyltransferases; MicroRNAs; Protein Biosynthesis; Cytoplasm