Structural basis of Nipah and Hendra virus attachment to their cell-surface receptor ephrin-B2.

Journal article

Nipah and Hendra viruses are emergent paramyxoviruses, causing disease characterized by rapid onset and high mortality rates, resulting in their classification as Biosafety Level 4 pathogens. Their attachment glycoproteins are essential for the recognition of the cell-surface receptors ephrin-B2 (EFNB2) and ephrin-B3 (EFNB3). Here we report crystal structures of both Nipah and Hendra attachment glycoproteins in complex with human EFNB2. In contrast to previously solved paramyxovirus attachmen...

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Authors: Bowden, T; Aricescu, A; Gilbert, R; Grimes, J; Jones, E

• Publication status: Published
• Journal: Nature structural and molecular biology
• Volume: 15
• Issue: 6
• Pages: 567-572
• Publication date: 2008-06-01
• DOI: 10.1038/nsmb.1435
• EISSN: 1545-9985
• ISSN: 1545-9993
• Language: English
• Keywords: Humans; Crystallography, X-Ray; Protein Conformation; Protein Binding; Receptors, Virus; Hendra Virus; Ephrin-B2; Virus Attachment; Viral Envelope Proteins; Nipah Virus; Paramyxoviridae