Journal article
TRIM21/Ro52 - Roles in innate immunity and autoimmune disease
- Abstract:
- TRIM21 (Ro52/SSA1) is an E3 ubiquitin ligase with key roles in immune host defence, signal transduction, and possibly cell cycle regulation. It is also an autoantibody target in Sjögren’s syndrome, systemic lupus erythematosus, and other rheumatic autoimmune diseases. Here, we summarise the structure and function of this enzyme, its roles in innate immunity, adaptive immunity and cellular homeostasis, the pathogenesis of autoimmunity against TRIM21, and the potential impacts of autoantibodies to this intracellular protein.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Preview, Version of record, pdf, 9.7MB, Terms of use)
-
- Publisher copy:
- 10.3389/fimmu.2021.738473
Authors
- Publisher:
- Frontiers Media
- Journal:
- Frontiers in Immunology More from this journal
- Volume:
- 12
- Article number:
- 738473
- Publication date:
- 2021-09-06
- Acceptance date:
- 2021-08-16
- DOI:
- EISSN:
-
1664-3224
- Language:
-
English
- Keywords:
- Pubs id:
-
1197236
- Local pid:
-
pubs:1197236
- Deposit date:
-
2021-10-01
- ARK identifier:
Terms of use
- Copyright holder:
- Jones et al.
- Copyright date:
- 2021
- Rights statement:
- © 2021 Jones, Laidlaw and Dustin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
- Licence:
- CC Attribution (CC BY)
If you are the owner of this record, you can report an update to it here: Report update to this record