Journal article
Bisphosphorylated PEA-15 sensitizes ovarian cancer cells to paclitaxel by impairing the microtubule-destabilizing effect of SCLIP.
- Abstract:
-
Paclitaxel is a standard chemotherapeutic agent for ovarian cancer. PEA-15 (phosphoprotein enriched in astrocytes-15 kDa) regulates cell proliferation, autophagy, apoptosis, and glucose metabolism and also mediates AKT-dependent chemoresistance in breast cancer. The functions of PEA-15 are tightly regulated by its phosphorylation status at Ser104 and Ser116. However, the effect of PEA-15 phosphorylation status on chemosensitivity of cancer cells remains unknown. Here, we tested the hypothesis...
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- Publisher copy:
- 10.1158/1535-7163.mct-12-0737
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Bibliographic Details
- Journal:
- Molecular cancer therapeutics
- Volume:
- 12
- Issue:
- 6
- Pages:
- 1099-1111
- Publication date:
- 2013-06-01
- DOI:
- EISSN:
-
1538-8514
- ISSN:
-
1535-7163
- Source identifiers:
-
410119
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:410119
- UUID:
-
uuid:653a9b56-5acc-4818-bb40-f4280c07fcd4
- Local pid:
- pubs:410119
- Deposit date:
- 2013-12-13
Terms of use
- Copyright date:
- 2013
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