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Bisphosphorylated PEA-15 sensitizes ovarian cancer cells to paclitaxel by impairing the microtubule-destabilizing effect of SCLIP.

Abstract:

Paclitaxel is a standard chemotherapeutic agent for ovarian cancer. PEA-15 (phosphoprotein enriched in astrocytes-15 kDa) regulates cell proliferation, autophagy, apoptosis, and glucose metabolism and also mediates AKT-dependent chemoresistance in breast cancer. The functions of PEA-15 are tightly regulated by its phosphorylation status at Ser104 and Ser116. However, the effect of PEA-15 phosphorylation status on chemosensitivity of cancer cells remains unknown. Here, we tested the hypothesis...

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Journal:
Molecular cancer therapeutics
Volume:
12
Issue:
6
Pages:
1099-1111
Publication date:
2013-06-05
DOI:
EISSN:
1538-8514
ISSN:
1535-7163
URN:
uuid:653a9b56-5acc-4818-bb40-f4280c07fcd4
Source identifiers:
410119
Local pid:
pubs:410119

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