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Thesis

Role of calcium mobilising messengers in cardiac arrhythmias

Abstract:

Nicotinic acid adenine dinucleotide phosphate (NAADP) is the most potent calcium ion (Ca2+) activating second messenger due to its ability to release Ca2+ from intracellular acidic stores at nanomolar concentrations. NAADP has been known to play an important role in controlling excitation-contraction coupling in the heart. The ADP-ribosyl cyclase (ARC) CD38, is believed to be responsible for the production of NAADP in the heart.

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Division:
MSD
Department:
Pharmacology
Role:
Author

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Role:
Supervisor
Role:
Supervisor


Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford


UUID:
uuid:65252aa0-400c-4357-80db-43a12e12e244
Deposit date:
2019-10-05

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