Journal article
Large-scale plasma metabolome analysis reveals alterations in HDL metabolism in migraine
- Abstract:
- OBJECTIVE:To identify a plasma metabolomic biomarker signature for migraine. METHODS:Plasma samples from 8 Dutch cohorts (n = 10,153: 2,800 migraine patients and 7,353 controls) were profiled on a 1H-NMR-based metabolomics platform, to quantify 146 individual metabolites (e.g., lipids, fatty acids, and lipoproteins) and 79 metabolite ratios. Metabolite measures associated with migraine were obtained after single-metabolite logistic regression combined with a random-effects meta-analysis performed in a nonstratified and sex-stratified manner. Next, a global test analysis was performed to identify sets of related metabolites associated with migraine. The Holm procedure was applied to control the family-wise error rate at 5% in single-metabolite and global test analyses. RESULTS:Decreases in the level of apolipoprotein A1 (β -0.10; 95% confidence interval [CI] -0.16, -0.05; adjusted p = 0.029) and free cholesterol to total lipid ratio present in small high-density lipoprotein subspecies (HDL) (β -0.10; 95% CI -0.15, -0.05; adjusted p = 0.029) were associated with migraine status. In addition, only in male participants, a decreased level of omega-3 fatty acids (β -0.24; 95% CI -0.36, -0.12; adjusted p = 0.033) was associated with migraine. Global test analysis further supported that HDL traits (but not other lipoproteins) were associated with migraine status. CONCLUSIONS:Metabolic profiling of plasma yielded alterations in HDL metabolism in migraine patients and decreased omega-3 fatty acids only in male migraineurs.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 570.0KB, Terms of use)
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- Publisher copy:
- 10.1212/wnl.0000000000007313
Authors
- Publisher:
- American Academy of Neurology
- Journal:
- Neurology More from this journal
- Volume:
- 92
- Issue:
- 16
- Pages:
- e1899-e1911
- Publication date:
- 2019-04-03
- Acceptance date:
- 2018-12-21
- DOI:
- EISSN:
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1526-632X
- ISSN:
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0028-3878
- Pmid:
-
30944236
- Language:
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English
- Keywords:
- Pubs id:
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pubs:999380
- UUID:
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uuid:651dbaa4-2b86-4679-a90e-9ab8bad81ab1
- Local pid:
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pubs:999380
- Source identifiers:
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999380
- Deposit date:
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2019-06-05
- ARK identifier:
Terms of use
- Copyright holder:
- Onderwater, GLJ et al
- Copyright date:
- 2019
- Notes:
- © 2019 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND), which permits downloading and sharing the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
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