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Hypothesis: cytokines may be activated to cause depressive illness and chronic fatigue syndrome.

Abstract:

Abnormalities in the regulation of the hypothalamo-pituitary-adrenal (HPA) axis are a well recognised feature of endogenous depression. The mechanism underlying this phenomenon remains obscure although there is strong evidence suggesting excessive CRH activity at the level of the hypothalamus. We propose a novel hypothesis in which we suggest that the aetiological antecent to CRH hyperactivity is cytokine activation in the brain. It is now well established both that interleukins -1 and -6 are...

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Publication status:
Published

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Publisher copy:
10.1007/bf02195983

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
Journal:
European archives of psychiatry and clinical neuroscience
Volume:
241
Issue:
5
Pages:
317-322
Publication date:
1992
DOI:
EISSN:
1433-8491
ISSN:
0940-1334
URN:
uuid:64f2a9a0-3a17-4944-8b93-88cc0adf8fbc
Source identifiers:
138188
Local pid:
pubs:138188

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