Insights into bunyavirus architecture from electron cryotomography of Uukuniemi virus.

Journal article

Bunyaviridae is a large family of viruses that have gained attention as "emerging viruses" because many members cause serious disease in humans, with an increasing number of outbreaks. These negative-strand RNA viruses possess a membrane envelope covered by glycoproteins. The virions are pleiomorphic and thus have not been amenable to structural characterization using common techniques that involve averaging of electron microscopic images. Here, we determined the three-dimensional structure o...

Expand abstract

Authors: Overby, A; Pettersson, R; Grünewald, K; Huiskonen, J

• Publication status: Published
• Journal: Proceedings of the National Academy of Sciences of the United States of America
• Volume: 105
• Issue: 7
• Pages: 2375-2379
• Publication date: 2008-02-01
• DOI: 10.1073/pnas.0708738105
• EISSN: 1091-6490
• ISSN: 0027-8424
• Language: English
• Keywords: Cryoelectron Microscopy; Hydrogen-Ion Concentration; Protein Conformation; Uukuniemi virus; Animals; Cell Line; Glycoproteins; Imaging, Three-Dimensional; Orthobunyavirus; Virion; Cell Membrane; Protein Binding; Ribonucleoproteins; Cricetinae