Journal article : Review
The assessment of antimalarial drug efficacy in vivo
- Abstract:
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Currently recommended methods of assessing the efficacy of uncomplicated falciparum malaria treatment work less well in high-transmission than in low-transmission settings. There is also uncertainty how to assess intermittent preventive therapies and seasonal malaria chemoprevention (SMC), and Plasmodium vivax radical cure. A pharmacometric antimalarial resistance monitoring (PARM) approach is proposed specifically for evaluating slowly eliminated antimalarial drugs in areas of high transmission. In PARM antimalarial drug concentrations at recurrent parasitaemia are measured to identify outliers (i.e., recurrent parasitaemias in the presence of normally suppressive drug concentrations) and to evaluate changes over time. PARM requires characterization of pharmacometric profiles but should be simpler and more sensitive than current molecular genotyping-based methodologies. PARM does not require parasite genotyping and can be applied to the assessment of both prevention and treatment.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Preview, Accepted manuscript, pdf, 1.2MB, Terms of use)
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- Publisher copy:
- 10.1016/j.pt.2022.05.008
Authors
- Publisher:
- Cell Press
- Journal:
- Trends in Parasitology More from this journal
- Volume:
- 38
- Issue:
- 8
- Pages:
- 660-672
- Publication date:
- 2022-06-06
- Acceptance date:
- 2022-05-16
- DOI:
- EISSN:
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1471-5007
- ISSN:
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1471-4922
- Pmid:
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35680541
- Language:
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English
- Keywords:
- Subtype:
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Review
- Pubs id:
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1263942
- Local pid:
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pubs:1263942
- Deposit date:
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2023-11-20
- ARK identifier:
Terms of use
- Copyright holder:
- Elsevier Ltd.
- Copyright date:
- 2022
- Rights statement:
- © 2022 Elsevier Ltd. All rights reserved.
- Notes:
-
The author is funded by the Wellcome Trust (093956). For the purpose of Open Access, the author has applied a CC BY public copyright licence to any Author Accepted Manuscript version arising from this submission.
This is the accepted manuscript version of the article. The final version is available online from Cell Press at https://dx.doi.org/10.1016/j.pt.2022.05.008
- Licence:
- CC Attribution (CC BY)
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