Journal article
Combining nucleoside analogues to achieve recognition of oligopurine tracts by triplex-forming oligonucleotides at physiological pH.
- Abstract:
-
We have used DNase I footprinting to examine DNA triple helix formation at a 12 base pair oligopurine.oligopyrimidine sequence, using oligonucleotides that contain combinations of 2'-aminoethoxy-5-(3-aminoprop-1-ynyl)uridine (bis-amino-U, BAU) and 3-methyl-2-aminopyridine (MeP) in place of T and C, respectively. This combination acts cooperatively to enable high affinity triple helix formation at physiological pH. The affinity depends on the number of substitutions and their arrangement; olig...
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- Publication status:
- Published
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- Publisher copy:
- 10.1016/j.febslet.2005.10.056
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Bibliographic Details
- Journal:
- FEBS letters
- Volume:
- 579
- Issue:
- 29
- Pages:
- 6616-6620
- Publication date:
- 2005-12-01
- DOI:
- EISSN:
-
1873-3468
- ISSN:
-
0014-5793
- Source identifiers:
-
400038
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:400038
- UUID:
-
uuid:64c98bf0-5be0-41e8-b8c8-671e2accc442
- Local pid:
- pubs:400038
- Deposit date:
- 2013-11-16
Terms of use
- Copyright date:
- 2005
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