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Combining nucleoside analogues to achieve recognition of oligopurine tracts by triplex-forming oligonucleotides at physiological pH.

Abstract:

We have used DNase I footprinting to examine DNA triple helix formation at a 12 base pair oligopurine.oligopyrimidine sequence, using oligonucleotides that contain combinations of 2'-aminoethoxy-5-(3-aminoprop-1-ynyl)uridine (bis-amino-U, BAU) and 3-methyl-2-aminopyridine (MeP) in place of T and C, respectively. This combination acts cooperatively to enable high affinity triple helix formation at physiological pH. The affinity depends on the number of substitutions and their arrangement; olig...

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Publication status:
Published

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Journal:
FEBS letters
Volume:
579
Issue:
29
Pages:
6616-6620
Publication date:
2005-12-01
DOI:
EISSN:
1873-3468
ISSN:
0014-5793
Source identifiers:
400038
Language:
English
Keywords:
Pubs id:
pubs:400038
UUID:
uuid:64c98bf0-5be0-41e8-b8c8-671e2accc442
Local pid:
pubs:400038
Deposit date:
2013-11-16

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