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Similar biological activities of two isostructural ruthenium and osmium complexes.

Abstract:

In this study, we probe and verify the concept of designing unreactive bioactive metal complexes, in which the metal possesses a purely structural function, by investigating the consequences of replacing ruthenium in a bioactive half-sandwich kinase inhibitor scaffold by its heavier congener osmium. The two isostructural complexes are compared with respect to their anticancer properties in 1205 Lu melanoma cells, activation of the Wnt signaling pathway, IC(50) values against the protein kinas...

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Publication status:
Published

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Publisher copy:
10.1002/chem.200800294

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Journal:
Chemistry (Weinheim an der Bergstrasse, Germany)
Volume:
14
Issue:
16
Pages:
4816-4822
Publication date:
2008-01-01
DOI:
EISSN:
1521-3765
ISSN:
0947-6539
Source identifiers:
40754
Language:
English
Keywords:
Pubs id:
pubs:40754
UUID:
uuid:64c3453f-8cfd-4858-a83e-0d446a066aaa
Local pid:
pubs:40754
Deposit date:
2012-12-19

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