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Autoimmunity to insulin receptor and hypoglycaemia in patient with Hodgkin's disease.

Abstract:

A 76-year-old man with fasting hypoglycaemia had impaired in-vitro binding of insulin to erythrocyte receptors. The immunoglobulin fraction of his plasma inhibited binding of insulin to normal donor erythrocytes in vitro. Autoantibodies may have stimulated the insulin receptor and produced hypoglycaemia. Hodgkin's disease developed and may have induced the autoimmunity. The hypoglycaemia did not respond to plasmapheresis or azathioprine alone, but it remitted after the addition of prednisolon...

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Authors


Braund, WJ More by this author
Naylor, BA More by this author
Williamson, DH More by this author
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Journal:
Lancet
Volume:
1
Issue:
8527
Pages:
237-240
Publication date:
1987-01-05
DOI:
EISSN:
1474-547X
ISSN:
0140-6736
URN:
uuid:649c93af-1b4d-4776-90a5-e912c35b94e8
Source identifiers:
371432
Local pid:
pubs:371432

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