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Co-evolutionary signals identify Burkholderia pseudomallei survival strategies in a hostile environment

Abstract:

The soil bacterium Burkholderia pseudomallei is the causative agent of melioidosis and a significant cause of human morbidity and mortality in many tropical and subtropical countries. The species notoriously survives harsh environmental conditions but the genetic architecture for these adaptations remains unclear. Here we employed a powerful combination of genome-wide epistasis and co-selection studies (2,011 genomes), condition-wide transcriptome analyses (82 diverse conditions), and a gene ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1093/molbev/msab306

Authors


Publisher:
Oxford University Press Publisher's website
Journal:
Molecular Biology and Evolution Journal website
Volume:
39
Issue:
1
Article number:
msab306
Publication date:
2021-10-18
Acceptance date:
2021-10-12
DOI:
EISSN:
1537-1719
ISSN:
0737-4038
Language:
English
Keywords:
Pubs id:
1207789
Local pid:
pubs:1207789
Deposit date:
2021-11-12

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