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Therapeutic hypothermia in experimental models of focal and global cerebral ischemia and intracerebral hemorrhage.

Abstract:

Experimental evidence shows that therapeutic hypothermia (TH) protects the brain from cerebral injury in multiple ways. In different models of focal and global cerebral ischemia, mild-to-moderate hypothermia reduces mortality and neuronal injury and improves neurological outcome. In models of experimental intracerebral hemorrhage (ICH), TH reduces edema formation but does not show consistent benefi cial effects on functional outcome parameters. However, the number of studies of hypothermia on...

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Publisher copy:
10.1586/14737175.8.8.1255

Authors


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Institution:
University of Oxford
Department:
Oxford
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Stroke and Geratology
Role:
Author
Journal:
Expert review of neurotherapeutics
Volume:
8
Issue:
8
Pages:
1255-1268
Publication date:
2008-08-05
DOI:
EISSN:
1744-8360
ISSN:
1473-7175
URN:
uuid:648ad891-c2c4-409c-9ad9-10c5bbfe7867
Source identifiers:
79176
Local pid:
pubs:79176

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