Therapeutic hypothermia in experimental models of focal and global cerebral ischemia and intracerebral hemorrhage.

Journal article

Experimental evidence shows that therapeutic hypothermia (TH) protects the brain from cerebral injury in multiple ways. In different models of focal and global cerebral ischemia, mild-to-moderate hypothermia reduces mortality and neuronal injury and improves neurological outcome. In models of experimental intracerebral hemorrhage (ICH), TH reduces edema formation but does not show consistent benefi cial effects on functional outcome parameters. However, the number of studies of hypothermia on...

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Authors: Nagel, S; Papadakis, M; Hoyte, L; Buchan, A

• Journal: Expert review of neurotherapeutics
• Volume: 8
• Issue: 8
• Pages: 1255-1268
• Publication date: 2008-08-01
• DOI: 10.1586/14737175.8.8.1255
• EISSN: 1744-8360
• ISSN: 1473-7175
• Language: English
• Keywords: Cerebral Hemorrhage; Disease Models, Animal; Humans; Brain Ischemia; Hypothermia, Induced; Treatment Outcome; Animals