Natural killer cell surveillance of intracellular antigen processing pathways mediated by recognition of HLA-E and Qa-1b by CD94/NKG2 receptors.

Journal article

HLA-E binds specifically to MHC class Ia leader peptides in a TAP (transporter associated with antigen processing)-dependent manner. It interacts with CD94/NKG2A receptors on natural killer cells and this inhibits natural killer cell lysis of the cell displaying HLA-E. The crystal structure of HLA-E demonstrates that the specificity of leader peptide binding is a structurally defined intrinsic property of HLA-E.

Authors: O'Callaghan, C

• Publication status: Published
• Journal: Microbes and infection / Institut Pasteur
• Volume: 2
• Issue: 4
• Pages: 371-380
• Publication date: 2000-04-01
• DOI: 10.1016/s1286-4579(00)00330-0
• EISSN: 1769-714X
• ISSN: 1286-4579
• Language: English
• Keywords: Histocompatibility Antigens Class I; Antigen Presentation; Models, Immunological; Antigens, CD; Animals; Receptors, Immunologic; NK Cell Lectin-Like Receptor Subfamily C; Receptors, Natural Killer Cell; Lectins, C-Type; NK Cell Lectin-Like Receptor Subfamily D; Killer Cells, Natural; Mice; HLA Antigens; Cytotoxicity, Immunologic; Membrane Glycoproteins; Protein Sorting Signals