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Natural killer cell surveillance of intracellular antigen processing pathways mediated by recognition of HLA-E and Qa-1b by CD94/NKG2 receptors.

Abstract:
HLA-E binds specifically to MHC class Ia leader peptides in a TAP (transporter associated with antigen processing)-dependent manner. It interacts with CD94/NKG2A receptors on natural killer cells and this inhibits natural killer cell lysis of the cell displaying HLA-E. The crystal structure of HLA-E demonstrates that the specificity of leader peptide binding is a structurally defined intrinsic property of HLA-E.
Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, CCMP
Journal:
Microbes and infection / Institut Pasteur
Volume:
2
Issue:
4
Pages:
371-380
Publication date:
2000-04-05
DOI:
EISSN:
1769-714X
ISSN:
1286-4579
URN:
uuid:6486c32e-e10c-4e16-8092-976ee07b1b3c
Source identifiers:
29171
Local pid:
pubs:29171

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