Journal article icon

Journal article

Plectoneme tip bubbles : coupled denaturation and writhing in supercoiled DNA

Abstract:

We predict a novel conformational regime for DNA, where denaturation bubbles form at the tips of plectonemes, and study its properties using coarse-grained simulations. For negative supercoiling, this regime lies between bubble-dominated and plectoneme-dominated phases, and explains the broad transition between the two observed in experiment. Tip bubbles cause localisation of plectonemes within thermodynamically weaker AT-rich sequences, and can greatly suppress plectoneme diffusion by a pinn...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

Actions


Access Document


Files:
Publisher copy:
10.1038/srep07655

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Rudolf Peierls Centre for Theoretical Physics
Role:
Author
Expand authors...
More from this funder
Funding agency for:
Matek, Christian
More from this funder
Funding agency for:
Ouldridge, Thomas E.
Engineering and Physical Sciences Research Council More from this funder
Publisher:
Nature Publishing Group Publisher's website
Journal:
Scientific Reports Journal website
Volume:
5
Pages:
Article: 7655
Publication date:
2015-01-05
DOI:
EISSN:
2045-2322
ISSN:
2045-2322
URN:
uuid:647ef7b6-ed11-456e-a351-059375615a29
Source identifiers:
462838
Local pid:
pubs:462838

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP