- Abstract:
-
We predict a novel conformational regime for DNA, where denaturation bubbles form at the tips of plectonemes, and study its properties using coarse-grained simulations. For negative supercoiling, this regime lies between bubble-dominated and plectoneme-dominated phases, and explains the broad transition between the two observed in experiment. Tip bubbles cause localisation of plectonemes within thermodynamically weaker AT-rich sequences, and can greatly suppress plectoneme diffusion by a pinn...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 867.9KB)
-
- Publisher copy:
- 10.1038/srep07655
-
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- Publisher:
- Nature Publishing Group Publisher's website
- Journal:
- Scientific Reports Journal website
- Volume:
- 5
- Pages:
- Article: 7655
- Publication date:
- 2015-01-05
- DOI:
- EISSN:
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2045-2322
- ISSN:
-
2045-2322
- URN:
-
uuid:647ef7b6-ed11-456e-a351-059375615a29
- Source identifiers:
-
462838
- Local pid:
- pubs:462838
- Language:
- English
- Keywords:
- Subjects:
- Copyright holder:
- Matek et al.
- Copyright date:
- 2015
- Notes:
-
5 pages + 26 pages Supplementary Material
Copyright © 2015 Matek et al. This work is licensed under a Creative Commons Attribution 4.0 International
License. The images or other third party material in this article are included in the
article’s Creative Commons license, unless indicated otherwise in the credit line; if
the material is not included under the Creative Commons license, users will need
to obtain permission from the license holder in order to reproduce the material. To
view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Journal article
Plectoneme tip bubbles : coupled denaturation and writhing in supercoiled DNA
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