Prostate volume and its correlation with histopathological outcomes in prostate cancer.

Journal article

INTRODUCTION: There is a paucity of data investigating the relationship between histopathological variables of oncologic importance and prostate volume, and we aimed to investigate this. PATIENTS AND METHODS: 2,207 consecutive patients who underwent robotic-assisted radical prostatectomy were studied. Preoperative demographic and both pre- and postoperative histopathological parameters were compared among the small (<40 cm(3)), intermediate (40-70 cm(3)), and large (>70 cm(3)) prostate groups. RESULTS: Patients with smaller prostates were younger, had slightly lower BMIs, and lower prostate-specific antigen (PSA) levels than those with larger prostates (p < 0.001). They also had worse histopathological criteria (Gleason, core positivity, and maximum percent cancer) on preoperative biopsy and had worse radical specimen Gleason sums (p < 0.001), percent cancer (p < 0.001), and pathological stage (p = 0.016). 11.5% of the men in the small prostate group suffered a positive surgical margin (PSM) compared to 8.3 and 5.6% in the intermediate and large prostate groups, respectively (p = 0.008). Basilar, posterolateral, and multifocal PSMs were commoner in the small prostate group. CONCLUSIONS: Younger men have smaller prostates and worse preoperative histopathological parameters despite lower PSA values. Men with small prostates undergoing robotic-assisted radical prostatectomy have worse final Gleason sums, tumour volume, extraprostatic extension, and PSM rates than those with larger prostates.

Authors: Sooriakumaran, P; Srivastava, A; Bhagat, D; John, M; Grover, S

• Journal: Urologia internationalis
• Volume: 86
• Issue: 2
• Pages: 152-155
• Publication date: 2011-01-01
• DOI: 10.1159/000322361
• EISSN: 1423-0399
• ISSN: 0042-1138
• Language: English
• Keywords: Treatment Outcome; Prostate; Humans; Organ Size; Prostate-Specific Antigen; Prognosis; Middle Aged; Male; Medical Oncology; Prostatectomy; Aged; Robotics; Prostatic Neoplasms; Biopsy