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Structural basis of outer membrane protein insertion by the BAM complex

Abstract:

All Gram-negative bacteria, mitochondria and chloroplasts have outer membrane proteins (OMPs) that perform many fundamental biological processes. The OMPs in Gram-negative bacteria are inserted and folded into the outer membrane by the β-barrel assembly machinery (BAM). The mechanism involved is poorly understood, owing to the absence of a structure of the entire BAM complex. Here we report two crystal structures of the Escherichia coli BAM complex in two distinct states: an inward-open st...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/nature17199

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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
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Funding agency for:
Dong, C
Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Journal website
Volume:
531
Pages:
64-69
Publication date:
2016-03-03
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
URN:
uuid:6455f020-ce8e-42d5-ac03-33457e631f5e
Source identifiers:
605636
Local pid:
pubs:605636

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