- Abstract:
-
In response to the Ebola virus (EBOV) crisis 2013-2016, a recombinant vesicular stomatitis virus (VSV)-based EBOV vaccine was clinically tested. A single-dose regimen of VSV-EBOV revealed a safe and immunogenic profile and demonstrated clinical efficacy. While EBOV-specific immune responses to this candidate vaccine have previously been investigated, limited human data on immunity to the VSV-vector are available. Within the scope of a Phase I study, we performed a comprehensive longitudinal a...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's Version
- Files:
-
-
(pdf, 597.7KB)
-
- Publisher copy:
- 10.1093/infdis/jiy565
-
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- Publisher:
- Oxford University Press Publisher's website
- Journal:
- Journal of Infectious Diseases Journal website
- Volume:
- 219
- Issue:
- 4
- Pages:
- 556–561
- Publication date:
- 2018-11-17
- Acceptance date:
- 2018-08-30
- DOI:
- EISSN:
-
1537-6613
- ISSN:
-
0022-1899
- Pubs id:
-
pubs:912009
- URN:
-
uri:643fa974-bc59-40ca-a77e-43eb6ca2660b
- UUID:
-
uuid:643fa974-bc59-40ca-a77e-43eb6ca2660b
- Local pid:
- pubs:912009
- Copyright holder:
- Poetsch et al.
- Copyright date:
- 2018
- Notes:
-
© The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Journal article
Detectable vesicular stomatitis virus (VSV)–specific humoral and cellular immune responses following VSV–Ebola virus vaccination in humans
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Funding
Wellcome Trust
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German Center for Infection Research
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Bundesministerium für Gesundheit
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German National Department for Education and Research
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