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Mapping diabetes QTL in an intercross derived from a congenic strain of the Brown Norway and Goto-Kakizaki rats.

Abstract:

Genetic studies in experimental crosses derived from the inbred Goto-Kakizaki (GK) rat model of spontaneous diabetes mellitus have identified quantitative trait loci (QTL) for diabetes phenotypes in a large region of rat Chromosome (RNO) 1. To test the impact of GK variants on QTL statistical and biological features, we combined genetic and physiologic studies in a cohort of F(2) hybrids derived from a QTL substitution congenic strain (QTLSCS) carrying a 110-cM GK haplotype of RNO1 introgress...

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Publication status:
Published

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Publisher copy:
10.1007/s00335-005-0168-y

Authors


Collins, SC More by this author
Wallis, RH More by this author
Wilder, SP More by this author
Wallace, KJ More by this author
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Journal:
Mammalian genome : official journal of the International Mammalian Genome Society
Volume:
17
Issue:
6
Pages:
538-547
Publication date:
2006-06-05
DOI:
EISSN:
1432-1777
ISSN:
0938-8990
URN:
uuid:643f2586-243f-4249-9c2a-7b696e447055
Source identifiers:
17636
Local pid:
pubs:17636

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