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Studies of mefloquine bioavailability and kinetics using a stable isotope technique: a comparison of Thai patients with falciparum malaria and healthy Caucasian volunteers.

Abstract:

1 A mefloquine hydrochloride tablet (250 mg base equivalent to 4.8 +/- 0.6 mg kg-1; mean +/- s.d.) and deuterium labelled mefloquine hydrochloride solution (250 mg base) were given to six adult male Thai patients with acute falciparum malaria and six healthy Swiss adult male volunteers (equivalent to 3.5 +/- 0.1 mg kg-1). 2 The relative bioavailability of the tablet formulation derived from comparison of the areas under the plasma concentration-time curves was similar in both groups; 87 +/- 1...

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Publication status:
Published

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Authors


Looareesuwan, S More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
Warrell, DA More by this author
Dubach, UG More by this author
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Journal:
British journal of clinical pharmacology
Volume:
24
Issue:
1
Pages:
37-42
Publication date:
1987-07-05
DOI:
EISSN:
1365-2125
ISSN:
0306-5251
URN:
uuid:6432ef69-22d4-4220-bffa-0fbefc474208
Source identifiers:
42870
Local pid:
pubs:42870

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