- Abstract:
- Aromatic analogues of the 2-oxoglutarate cosubstrate of the hypoxia-inducible factor hydroxylases are shown to bind at the active site iron: Pyridine-2,4-dicarboxylate binds as anticipated with a single molecule chelating the iron in a bidentate manner. The binding mode of a hydroxamic acid analogue, at least in the crystalline state, is unusual because two molecules of the inhibitor are observed at the active site and partial displacement of the iron binding aspartyl residue was observed.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Accepted Manuscript
- Files:
-
-
(pdf, 384.1KB)
-
(pdf, 393.7KB)
-
(pdf, 70.2KB)
-
- Publisher copy:
- 10.1016/j.bmcl.2010.08.032
-
Version unsuitable
-
We have not obtained a suitable full-text for a given research output. See this page for more information.
-
Recently completed
-
Sometimes content is held in ORA but is unavailable for a fixed period of time to comply with the policies and wishes of rights holders.
-
Permissions
-
All content made available in ORA should comply with relevant rights, such as copyright. See this page for more information.
-
Clearance
-
Some thesis volumes scanned as part of the digitisation scheme funded by Dr Leonard Polonsky are currently unavailable due to sensitive material or uncleared third-party copyright content. We are attempting to contact authors whose theses are affected.
- Institution:
- University of Oxford
- Department:
- Mathematical,Physical & Life Sciences Division - Chemistry - Chemistry Research Laboratory
- Role:
- Researcher
- Institution:
- University of Oxford
- Oxford college:
- St Edmund Hall
- Role:
- Researcher
- Institution:
- University of Oxford
- Department:
- Mathematical,Physical & Life Sciences Division - Chemistry - Chemistry Research Laboratory
- Role:
- Researcher
- Institution:
- University of Oxford
- Department:
- Mathematical,Physical & Life Sciences Division - Chemistry - Chemistry Research Laboratory
- Role:
- Researcher
- Funding agency for:
- Ana Conejo-Garcia
- Publisher:
- Elsevier Publisher's website
- Journal:
- Bioorganic & Medicinal Chemistry Letters Journal website
- Volume:
- 20
- Issue:
- 20
- Pages:
- 6125-6128
- Publication date:
- 2010-10-04
- DOI:
- ISSN:
-
0960-894X
- URN:
-
uuid:64146860-e31b-481f-9ff8-28a593a0b108
- Local pid:
- ora:5447
- Language:
- English
- Keywords:
- Subjects:
- Copyright holder:
- Elsevier
- Copyright date:
- 2010
Journal article
Structural basis for binding of cyclic 2-oxoglutarate analogues to factor-inhibiting hypoxia-inducible factor
Actions
Access Document
Why is the content I wish to access not available via ORA?
Bibliographic data (the information relating to research outputs) and full-text items (e.g. articles, theses, reports, etc.) arrive in ORA from several different sources. Unfortunately we are not able to make available the full-text for every research output.
Please contact the ORA team (
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
Content may be unavailable for the following four reasons
Alternative access to the full-text
You may be able to access the full-text directly from the publisher's website using the 'Publisher Copy' link in the 'Links & Downloads' box from a research output's ORA record page. This method may require an institutional or individual subscription to the journal/resource.
Authors
Contributors
+ Luke A. McNeill
+ Kirsty S. Hewitson
+ Wei Ge
+ Benoît M. Liénard
Funding
+ European Commision : Marie Curie programme
More from this funder
Bibliographic Details
Item Description
Terms of use
If you are the owner of this record, you can report an update to it here: Report update to this record