Journal article
Oocyte-specific ablation of N- and O-glycans alters cumulus cell signalling and extracellular matrix composition
- Abstract:
-
Cumulus–oocyte complex (COC) expansion is essential for ovulation and fertilisation and is linked to oocyte quality. Hyaluronan (HA), the major matrix constituent, is cross-linked via inter-α-inhibitor heavy chains (HCs), pentraxin 3 (PTX3) and tumour necrosis factor-stimulated gene 6 (TSG-6). All except HCs are secreted by cumulus cells in response to oocyte-secreted factors, which signal via SMAD pathways. The double mutant (DM) mouse generates oocytes lacking complex N- and O-glycans due t...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Accepted manuscript, jpeg, 556.2KB)
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(Accepted manuscript, jpeg, 395.6KB)
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(Accepted manuscript, jpeg, 919.1KB)
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(Accepted manuscript, jpeg, 772.2KB)
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(Accepted manuscript, pdf, 181.8KB)
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- Publisher copy:
- 10.1071/rd18209
Authors
Bibliographic Details
- Publisher:
- CSIRO Publishing Publisher's website
- Journal:
- Reproduction, Fertility and Development Journal website
- Volume:
- 31
- Issue:
- 3
- Pages:
- 529-537
- Publication date:
- 2018-10-30
- Acceptance date:
- 2018-09-08
- DOI:
- EISSN:
-
1448-5990
- ISSN:
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1031-3613
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:946102
- UUID:
-
uuid:63f8ded8-a29f-46d0-bd79-d568fd57203d
- Local pid:
- pubs:946102
- Source identifiers:
-
946102
- Deposit date:
- 2019-02-01
Terms of use
- Copyright holder:
- CSIRO
- Copyright date:
- 2018
- Notes:
- This is the accepted manuscript version of the article. The final version is available online from CSIRO Publishing at: https://doi.org/10.1071/rd18209
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