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Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis

Abstract:

Rheumatoid arthritis (RA) is a prevalent systemic autoimmune disease, caused by a combination of genetic and environmental factors. Animal models suggest a role for intestinal bacteria in supporting the systemic immune response required for joint inflammation. Here we performed 16S sequencing on 114 stool samples from rheumatoid arthritis patients and controls, and shotgun sequencing on a subset of 44 such samples. We identified the presence of Prevotella copri as strongly correlated with dis...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.7554/eLife.01202.001

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Publisher:
eLife Sciences Publications
Journal:
eLife More from this journal
Volume:
2013
Issue:
2
Article number:
e01202
Publication date:
2013-11-05
Acceptance date:
2013-09-25
DOI:
EISSN:
2050-084X
Language:
English
Keywords:
Pubs id:
pubs:438783
UUID:
uuid:63f72163-d3ca-4a01-8074-f54d46a4bc5c
Local pid:
pubs:438783
Source identifiers:
438783
Deposit date:
2014-05-12

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