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On the mechanism of loading the PCNA sliding clamp by RFC.

Abstract:

Sliding clamps play central roles in a broad range of DNA replication and repair processes. The clamps form circular molecules that must be opened and resealed around DNA by the clamp loader complex to fulfil their function. While most eukaryotes and many archea possess a homo-trimeric PCNA, the PCNA of Sulfolobus solfataricus is a heterotrimer. Here, we exploit the asymmetry of S. solfataricus PCNA to create a series of circularly permuted PCNA subunit fusions, thereby covalently closing def...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Journal:
Molecular microbiology More from this journal
Volume:
68
Issue:
1
Pages:
216-222
Publication date:
2008-04-01
DOI:
EISSN:
1365-2958
ISSN:
0950-382X
Language:
English
Keywords:
Pubs id:
pubs:26818
UUID:
uuid:63ebb39b-00b4-4438-bae6-1343be39ce1f
Local pid:
pubs:26818
Source identifiers:
26818
Deposit date:
2012-12-19

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