The RNA binding proteins TIA1 and TIAL1 promote Mcl1 mRNA translation to protect germinal center responses from apoptosis

Journal article

In yeast, import of most mitochondrial proteins requires that their precursor proteins are bound by the peripheral receptor proteins Tom20, Tom22, and Tom70, a process conserved from yeast to mammals. For budding yeast Tom20 and Tom70, there is evidence of specific yet overlapping substrate recognition, however, no such data is available for the metazoan cells. Although mitochondrial protein import has been extensively studied in past years, the cytosolic stage of this process remains enigmat...

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Authors: Osma-Garcia, IC; Mouysset, M; Capitan-Sobrino, D; Aubert, Y; Turner, M

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Springer Nature [academic journals on nature.com]
• Journal: Cellular & Molecular Immunology
• Volume: 20
• Issue: 9
• Pages: 1063-1076
• Publication date: 2023-07-20
• DOI: 10.1038/s41423-023-01063-4
• EISSN: 2042-0226
• ISSN: 1672-7681
• Language: English
• Keywords: Messenger RNA; Transcriptional regulation; Molecular biology; Proteome; Downregulation and upregulation; Translational regulation; Gene expression; Antibody; microRNA; Cell biology; MCL1; Biology; Genetics; B cell; Translation (biology); Germinal center; RNA-binding protein; Gene; RNA