- Abstract:
-
Adhesive interactions involving CD44, the cell surface receptor for hyaluronan, underlie fundamental processes such as inflammatory leukocyte homing and tumor metastasis. Regulation of such events is critical and appears to be effected by changes in CD44 N-glycosylation that switch the receptor "on" or "off" under appropriate circumstances. How altered glycosylation influences binding of hyaluronan to the lectin-like Link module in CD44 is unclear, although evidence suggests additional flanki...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/s1097-2765(04)00080-2
-
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- Journal:
- Molecular cell
- Volume:
- 13
- Issue:
- 4
- Pages:
- 483-496
- Publication date:
- 2004-02-05
- DOI:
- EISSN:
-
1097-4164
- ISSN:
-
1097-2765
- URN:
-
uuid:63ad26c7-6c8e-464d-a7b6-d9e7dce37ccc
- Source identifiers:
-
58745
- Local pid:
- pubs:58745
- Language:
- English
- Keywords:
- Copyright date:
- 2004
Journal article
Structure of the regulatory hyaluronan binding domain in the inflammatory leukocyte homing receptor CD44.
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