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Journal article

Structure of the regulatory hyaluronan binding domain in the inflammatory leukocyte homing receptor CD44.

Abstract:

Adhesive interactions involving CD44, the cell surface receptor for hyaluronan, underlie fundamental processes such as inflammatory leukocyte homing and tumor metastasis. Regulation of such events is critical and appears to be effected by changes in CD44 N-glycosylation that switch the receptor "on" or "off" under appropriate circumstances. How altered glycosylation influences binding of hyaluronan to the lectin-like Link module in CD44 is unclear, although evidence suggests additional flanki...

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Publication status:
Published

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Journal:
Molecular cell
Volume:
13
Issue:
4
Pages:
483-496
Publication date:
2004-02-05
DOI:
EISSN:
1097-4164
ISSN:
1097-2765
URN:
uuid:63ad26c7-6c8e-464d-a7b6-d9e7dce37ccc
Source identifiers:
58745
Local pid:
pubs:58745

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