Bilayer-mediated clustering and functional interaction of MscL channels.

Journal article

Mechanosensitive channels allow bacteria to respond to osmotic stress by opening a nanometer-sized pore in the cellular membrane. Although the underlying mechanism has been thoroughly studied on the basis of individual channels, the behavior of channel ensembles has yet to be elucidated. This work reveals that mechanosensitive channels of large conductance (MscL) exhibit a tendency to spatially cluster, and demonstrates the functional relevance of clustering. We evaluated the spatial distribu...

Expand abstract

Authors: Grage, S; Keleshian, A; Turdzeladze, T; Battle, A; Tay, W

• Publication status: Published
• Journal: Biophysical journal
• Volume: 100
• Issue: 5
• Pages: 1252-1260
• Publication date: 2011-03-01
• DOI: 10.1016/j.bpj.2011.01.023
• EISSN: 1542-0086
• ISSN: 0006-3495
• Language: English
• Keywords: Protein Binding; Microscopy, Atomic Force; Liposomes; Escherichia coli; Cell Membrane; Neutron Diffraction; Lipid Bilayers; Scattering, Small Angle; Ion Channels; Escherichia coli Proteins