Delayed repair of radiation induced clustered DNA damage: Friend or foe?

Journal article

A signature of ionizing radiation exposure is the induction of DNA clustered damaged sites, defined as two or more lesions within one to two helical turns of DNA by passage of a single radiation track. Clustered damage is made up of double strand breaks (DSB) with associated base lesions or abasic (AP) sites, and non-DSB clusters comprised of base lesions, AP sites and single strand breaks. This review will concentrate on the experimental findings of the processing of non-DSB clustered damage...

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Authors: Eccles, L; O'Neill, P; Lomax, M

• Journal: Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
• Volume: 711
• Issue: 1-2
• Pages: 134-141
• Publication date: 2011-06-03
• DOI: 10.1016/j.mrfmmm.2010.11.003
• EISSN: 0921-8262
• ISSN: 0027-5107
• Language: English
• Keywords: Non-DSB clusters; Base excision repair; Mutation induction; Ionizing radiation