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Delayed repair of radiation induced clustered DNA damage: Friend or foe?

Abstract:

A signature of ionizing radiation exposure is the induction of DNA clustered damaged sites, defined as two or more lesions within one to two helical turns of DNA by passage of a single radiation track. Clustered damage is made up of double strand breaks (DSB) with associated base lesions or abasic (AP) sites, and non-DSB clusters comprised of base lesions, AP sites and single strand breaks. This review will concentrate on the experimental findings of the processing of non-DSB clustered damage...

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Journal:
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis More from this journal
Volume:
711
Issue:
1-2
Pages:
134-141
Publication date:
2011-06-03
DOI:
EISSN:
0921-8262
ISSN:
0027-5107
Language:
English
Keywords:
Pubs id:
pubs:149915
UUID:
uuid:63ac44d8-e0d9-4a8c-a5e8-1e6e06d34be8
Local pid:
pubs:149915
Source identifiers:
149915
Deposit date:
2012-12-19

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