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HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors.

Abstract:

Solid tumors contain regions of hypoxia, a physiological stress that can activate cell death pathways and, thus, result in the selection of cells resistant to death signals and anticancer therapy. Bcl2/adenovirus EIB 19kD-interacting protein 3 (BNIP3) is a cell death factor that is a member of the Bcl-2 proapoptotic family recently shown to induce necrosis rather than apoptosis. Using cDNA arrays and serial analysis of gene expression, we found that hypoxia induces up-regulation of BNIP3 and ...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, CCMP, Biomedical Research Centre
Role:
Author
Journal:
Cancer research
Volume:
61
Issue:
18
Pages:
6669-6673
Publication date:
2001-09-05
EISSN:
1538-7445
ISSN:
0008-5472
URN:
uuid:639ec456-8633-41e9-aaa1-5d38090ea42e
Source identifiers:
30450
Local pid:
pubs:30450

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