Journal article
The repertoire of serous ovarian cancer non-genetic heterogeneity revealed by single-cell sequencing of normal fallopian tube epithelial cells
- Abstract:
- The inter-differentiation between cell states promotes cancer cell survival under stress and fosters non-genetic heterogeneity (NGH). NGH is, therefore, a surrogate of tumor resilience but its quantification is confounded by genetic heterogeneity. Here we show that NGH in serous ovarian cancer (SOC) can be accurately measured when informed by the molecular signatures of the normal fallopian tube epithelium (FTE) cells, the cells of origin of SOC. Surveying the transcriptomes of ∼6,000 FTE cells, predominantly from non-ovarian cancer patients, identified 6 FTE subtypes. We used subtype signatures to deconvolute SOC expression data and found substantial intra-tumor NGH. Importantly, NGH-based stratification of ∼1,700 tumors robustly correlated with survival. Our findings lay the foundation for accurate prognostic and therapeutic stratification of SOC.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Accepted manuscript, 1.8MB, Terms of use)
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- Publisher copy:
- 10.1016/j.ccell.2020.01.003
Authors
- Publisher:
- Cell Press
- Journal:
- Cancer Cell More from this journal
- Volume:
- 37
- Issue:
- 2
- Pages:
- 226-242.e7
- Publication date:
- 2020-02-10
- Acceptance date:
- 2020-01-09
- DOI:
- EISSN:
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1878-3686
- ISSN:
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1535-6108
- Language:
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English
- Keywords:
- Pubs id:
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1083700
- Local pid:
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pubs:1083700
- Deposit date:
-
2020-01-29
Terms of use
- Copyright holder:
- Elsevier Inc.
- Copyright date:
- 2020
- Rights statement:
- © 2020 Elsevier Inc.
- Notes:
- This is the accepted manuscript version of the article. The final version is available online from Elsevier at: https://doi.org/10.1016/j.ccell.2020.01.003
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