Journal article
The repertoire of serous ovarian cancer non-genetic heterogeneity revealed by single-cell sequencing of normal fallopian tube epithelial cells
- Abstract:
-
The inter-differentiation between cell states promotes cancer cell survival under stress and fosters non-genetic heterogeneity (NGH). NGH is, therefore, a surrogate of tumor resilience but its quantification is confounded by genetic heterogeneity. Here we show that NGH in serous ovarian cancer (SOC) can be accurately measured when informed by the molecular signatures of the normal fallopian tube epithelium (FTE) cells, the cells of origin of SOC. Surveying the transcriptomes of ∼6,000 FTE cel...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Bibliographic Details
- Publisher:
- Cell Press Publisher's website
- Journal:
- Cancer Cell Journal website
- Volume:
- 37
- Issue:
- 2
- Pages:
- 226-242.e7
- Publication date:
- 2020-02-10
- Acceptance date:
- 2020-01-09
- DOI:
- EISSN:
-
1878-3686
- ISSN:
-
1535-6108
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
1083700
- Local pid:
- pubs:1083700
- Deposit date:
- 2020-01-29
Terms of use
- Copyright holder:
- Elsevier Inc.
- Copyright date:
- 2020
- Rights statement:
- © 2020 Elsevier Inc.
- Notes:
- This is the accepted manuscript version of the article. The final version is available online from Elsevier at: https://doi.org/10.1016/j.ccell.2020.01.003
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