Journal article
Allosteric activation of an ion channel triggered by modification of mechanosensitive nano-pockets
- Abstract:
-
Lipid availability within transmembrane nano-pockets of ion channels is linked with mechanosensation. However, the effect of hindering lipid-chain penetration into nano-pockets on channel structure has not been demonstrated. Here we identify nano-pockets on the large conductance mechanosensitive channel MscL, the high-pressure threshold channel. We restrict lipid-chain access to the nano-pockets by mutagenesis and sulfhydryl modification, and monitor channel conformation by PELDOR/DEER spectr...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Bibliographic Details
- Publisher:
- Springer Nature Publisher's website
- Journal:
- Nature Communications Journal website
- Volume:
- 10
- Issue:
- 1
- Article number:
- 4619
- Publication date:
- 2019-10-10
- Acceptance date:
- 2019-09-17
- DOI:
- EISSN:
-
2041-1723
- Pmid:
-
31601809
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
1062804
- Local pid:
- pubs:1062804
- Deposit date:
- 2020-06-15
Terms of use
- Copyright holder:
- Kapsalis et al.
- Copyright date:
- 2019
- Rights statement:
- © The Author(s) 2019. This article is licensed under a Creative Commons Attribution 4.0 International License
- Licence:
- CC Attribution (CC BY)
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