Variation in the TNF-alpha promoter region associated with susceptibility to cerebral malaria.

Journal article

Tumour-necrosis factor-alpha (TNF-alpha) is believed to have an important role in the pathogenesis of severe infectious disease and fatal cerebral malaria is associated with high circulating levels of this cytokine. In a large case-control study in Gambian children we find that homozygotes for the TNF2 allele, a variant of the TNF-alpha gene promoter region, have a relative risk of 7 for death or severe neurological sequelae due to cerebral malaria. Although the TNF2 allele is in linkage dise...

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Authors: McGuire, W; Hill, A; Allsopp, C; Greenwood, B; Kwiatkowski, D

• Publication status: Published
• Journal: Nature
• Volume: 371
• Issue: 6497
• Pages: 508-510
• Publication date: 1994-10-01
• DOI: 10.1038/371508a0
• EISSN: 1476-4687
• ISSN: 0028-0836
• Language: English
• Keywords: DNA Primers; Base Sequence; Gene Frequency; Gambia; Child; Histocompatibility Testing; Child, Preschool; Humans; Genetic Predisposition to Disease; Plasmodium falciparum; HLA Antigens; Promoter Regions, Genetic; Animals; Polymorphism, Genetic; Tumor Necrosis Factor-alpha; Malaria, Cerebral; Infant; Case-Control Studies; Alleles; Molecular Sequence Data