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Variation in the TNF-alpha promoter region associated with susceptibility to cerebral malaria.

Abstract:

Tumour-necrosis factor-alpha (TNF-alpha) is believed to have an important role in the pathogenesis of severe infectious disease and fatal cerebral malaria is associated with high circulating levels of this cytokine. In a large case-control study in Gambian children we find that homozygotes for the TNF2 allele, a variant of the TNF-alpha gene promoter region, have a relative risk of 7 for death or severe neurological sequelae due to cerebral malaria. Although the TNF2 allele is in linkage dise...

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Publication status:
Published

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Publisher copy:
10.1038/371508a0

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
Journal:
Nature More from this journal
Volume:
371
Issue:
6497
Pages:
508-510
Publication date:
1994-10-01
DOI:
EISSN:
1476-4687
ISSN:
0028-0836

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