Journal article
Suboptimal exposure to anti-TB drugs in a TBM/HIV+ population is not related to anti-retroviral therapy.
- Abstract:
-
A placebo-controlled trial that compares the outcomes of immediate versus deferred initiation of antiretroviral therapy in HIV+ve Tuberculous Meningitis (TBM) patients was conducted in Vietnam in 2011. Here, the pharmacokinetics of Rifampicin, Isoniazid, Pyrazinamide and Ethambutol were investigated in the presence and absence of anti-HIV treatment in 85 patients. Pharmacokinetic analyses show that HIV therapy has no significant impact upon the pharmacokinetics of TB drugs in this cohort. The...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Wellcome Trust
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Bibliographic Details
- Publisher:
- Wiley Publisher's website
- Journal:
- Clinical Pharmacology and Therapeutics Journal website
- Volume:
- 103
- Pages:
- 449–457
- Publication date:
- 2017-02-01
- Acceptance date:
- 2017-01-29
- DOI:
Item Description
- Keywords:
- Pubs id:
-
pubs:682313
- UUID:
-
uuid:636857d0-dc52-476b-9677-9bc4af844d9a
- Local pid:
- pubs:682313
- Source identifiers:
-
682313
- Deposit date:
- 2017-02-28
Terms of use
- Copyright holder:
- American Society for Clinical Pharmacology and Therapeutics
- Copyright date:
- 2017
- Notes:
- © 2017 American Society for Clinical Pharmacology and Therapeutics
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