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Insulin granule dynamics in pancreatic beta cells.

Abstract:

Glucose-induced insulin secretion in response to a step increase in blood glucose concentrations follows a biphasic time course consisting of a rapid and transient first phase followed by a slowly developing and sustained second phase. Because Type 2 diabetes involves defects of insulin secretion, manifested as a loss of first phase and a reduction of second phase, it is important to understand the cellular mechanisms underlying biphasic insulin secretion. Insulin release involves the packagi...

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Publication status:
Published

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Publisher copy:
10.1007/s00125-003-1153-1

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Role:
Author
Journal:
Diabetologia More from this journal
Volume:
46
Issue:
8
Pages:
1029-1045
Publication date:
2003-08-01
DOI:
EISSN:
1432-0428
ISSN:
0012-186X
Language:
English
Keywords:
Pubs id:
pubs:29409
UUID:
uuid:635ba3a3-72d0-46ce-a555-2274135ddfdb
Local pid:
pubs:29409
Source identifiers:
29409
Deposit date:
2012-12-19

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