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Journal article

Lipid metabolism fattens up hedgehog signaling

Abstract:

Signaling pathways direct organogenesis, often through concentration-dependent effects on cells. The hedgehog pathway enables cells to sense and respond to hedgehog ligands, of which the best studied is sonic hedgehog. Hedgehog signaling is essential for development, proliferation, and stem cell maintenance, and it is a driver of certain cancers. Lipid metabolism has a profound influence on both hedgehog signal transduction and the properties of the ligands themselves, leading to changes i...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's copy

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Publisher copy:
10.1186/s12915-017-0442-y

Authors


Blassberg, R More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
Publisher:
BioMed Central Ltd Publisher's website
Journal:
BMC Biology Journal website
Volume:
15
Issue:
1
Publication date:
2017-10-26
DOI:
EISSN:
1741-7007
Pubs id:
pubs:798042
URN:
uri:635b6c56-19bc-4434-9eda-d411696e7431
UUID:
uuid:635b6c56-19bc-4434-9eda-d411696e7431
Local pid:
pubs:798042

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