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Wapl repression by Pax5 promotes V gene recombination by Igh loop extrusion

Abstract:

Nuclear processes, such as V(D)J recombination, are orchestrated by the three-dimensional organization of chromosomes at multiple levels, including compartments1 and topologically associated domains (TADs)2,3 consisting of chromatin loops4. TADs are formed by chromatin-loop extrusion5,6,7, which depends on the loop-extrusion function of the ring-shaped cohesin complex8,9,10,11,12. Conversely, the cohesin-release factor Wapl13,14 restricts loop extension10,15. The generation of a diverse antib...

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Publication status:
Published
Peer review status:
Peer reviewed

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Role:
Author
ORCID:
0000-0002-2425-473X
Publisher:
Springer Nature
Journal:
Nature More from this journal
Volume:
584
Pages:
142–147
Publication date:
2020-07-01
Acceptance date:
2020-04-09
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
Pmid:
32612238
Language:
English
Keywords:
Pubs id:
1116386
Local pid:
pubs:1116386
Deposit date:
2020-07-10

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