Integrating case-control and TDT studies.

Journal article

Genetic-association studies are widely expected to unravel the genetic basis of complex diseases. The population-based case-control study, a commonly used approach for association studies, is subject to the problem of population admixture. Consequently, evidence of disease-marker associations obtained from such studies is ideally confirmed by alternative methods. The Transmission/Disequilibrium Test (TDT) is suitable to assess evidence of association obtained from case-control studies. Since ...

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Authors: Kazeem, G; Farrall, M

• Publication status: Published
• Journal: Annals of human genetics
• Volume: 69
• Issue: Pt 3
• Pages: 329-335
• Publication date: 2005-05-01
• DOI: 10.1046/j.1529-8817.2005.00156.x
• EISSN: 1469-1809
• ISSN: 0003-4800
• Language: English
• Keywords: Odds Ratio; Case-Control Studies; Genetic Predisposition to Disease; Research Design; Diabetes Mellitus, Type 2; Models, Theoretical; Genetic Markers; Linkage Disequilibrium; Humans; Haplotypes