Journal article
NMR analyses on N-hydroxymethylated nucleobases - implications for formaldehyde toxicity and nucleic acid demethylases
- Abstract:
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Formaldehyde is produced in cells by enzyme-catalysed demethylation reactions, including those occurring on N-methylated nucleic acids. Formaldehyde reacts with nucleobases to form N-hydroxymethylated adducts that may contribute to its toxicity/carcinogenicity when added exogenously, but the chemistry of these reactions has been incompletely defined. We report NMR studies on the reactions of formaldehyde with canonical/modified nucleobases. The results reveal that hydroxymethyl hemiaminals on...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 2.9MB)
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- Publisher copy:
- 10.1039/c8ob00734a
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Authors
Funding
Bibliographic Details
- Publisher:
- Royal Society of Chemistry Publisher's website
- Journal:
- Organic and Biomolecular Chemistry Journal website
- Volume:
- 16
- Issue:
- 21
- Pages:
- 4021-4032
- Publication date:
- 2018-05-16
- Acceptance date:
- 2018-03-29
- DOI:
- EISSN:
-
1477-0539
- ISSN:
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1477-0520
- Pmid:
-
29767200
- Source identifiers:
-
848161
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:848161
- UUID:
-
uuid:63332b76-e441-4e74-84e4-7f11c15ab698
- Local pid:
- pubs:848161
- Deposit date:
- 2018-06-19
Terms of use
- Copyright holder:
- Royal Society of Chemistry
- Copyright date:
- 2018
- Notes:
- © The Royal Society of Chemistry 2018. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
- Licence:
- CC Attribution (CC BY)
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