Application of coalescent methods to reveal fine-scale rate variation and recombination hotspots.

Journal article

There has been considerable recent interest in understanding the way in which recombination rates vary over small physical distances, and the extent of recombination hotspots, in various genomes. Here we adapt, apply, and assess the power of recently developed coalescent-based approaches to estimating recombination rates from sequence polymorphism data. We apply full-likelihood estimation to study rate variation in and around a well-characterized recombination hotspot in humans, in the beta-g...

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Authors: Fearnhead, P; Harding, R; Schneider, J; Myers, S; Donnelly, P

• Publication status: Published
• Journal: Genetics
• Volume: 167
• Issue: 4
• Pages: 2067-2081
• Publication date: 2004-08-01
• DOI: 10.1534/genetics.103.021584
• EISSN: 1943-2631
• ISSN: 0016-6731
• Language: English
• Keywords: Genome; Recombination, Genetic; Models, Statistical; Genetic Variation; Haplotypes; Models, Genetic; Globins; Humans; Likelihood Functions; DNA