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Journal article

Application of coalescent methods to reveal fine-scale rate variation and recombination hotspots.

Abstract:

There has been considerable recent interest in understanding the way in which recombination rates vary over small physical distances, and the extent of recombination hotspots, in various genomes. Here we adapt, apply, and assess the power of recently developed coalescent-based approaches to estimating recombination rates from sequence polymorphism data. We apply full-likelihood estimation to study rate variation in and around a well-characterized recombination hotspot in humans, in the beta-g...

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Publication status:
Published

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Publisher copy:
10.1534/genetics.103.021584
Journal:
Genetics More from this journal
Volume:
167
Issue:
4
Pages:
2067-2081
Publication date:
2004-08-01
DOI:
EISSN:
1943-2631
ISSN:
0016-6731
Language:
English
Keywords:
Pubs id:
pubs:50017
UUID:
uuid:631e1bca-17fe-41c9-8ae4-9df319ba561c
Local pid:
pubs:50017
Source identifiers:
50017
Deposit date:
2012-12-19

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