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MOMP from Campylobacter jejuni is a trimer of 18-stranded β-barrel monomers with a Ca(2+) ion bound at the constriction zone.

Abstract:

The Gram-negative organism Campylobacter jejuni is the major cause of food poisoning. Unlike Escherichia coli, which has two major porins, OmpC and OmpF, C. jejuni has one, termed major outer membrane protein (MOMP) through which nutrients and antibiotics transit. We report the 2.1-Å crystal structure of C. jejuni MOMP expressed in E. coli and a lower resolution but otherwise identical structure purified directly from C. jejuni. The 2.1-Å resolution structure of recombinant MOMP showed that a...

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Publication status:
Published
Peer review status:
Peer reviewed

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Authors


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Name:
Wellcome Trust
Grant:
WT100209MA
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Name:
Royal Society
Grant:
Wolfson Merit Award
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Name:
Innovative Medicines Initiatives Joint Undertaking
Grant:
115525
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Name:
Seventh Framework Programme
Grant:
607694
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Name:
Chinese Academy of Science
Publisher:
Elsevier
Journal:
Journal of Molecular Biology More from this journal
Volume:
428
Issue:
22
Pages:
4528-4543
Publication date:
2016-09-01
Acceptance date:
2016-09-26
DOI:
EISSN:
1089-8638
ISSN:
0022-2836

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