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MOMP from Campylobacter jejuni is a trimer of 18-stranded β-barrel monomers with a Ca(2+) ion bound at the constriction zone.

Abstract:

The Gram-negative organism Campylobacter jejuni is the major cause of food poisoning. Unlike Escherichia coli, which has two major porins, OmpC and OmpF, C. jejuni has one, termed major outer membrane protein (MOMP) through which nutrients and antibiotics transit. We report the 2.1-Å crystal structure of C. jejuni MOMP expressed in E. coli and a lower resolution but otherwise identical structure purified directly from C. jejuni. The 2.1-Å resolution structure of recombinant MOMP showed that a...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.jmb.2016.09.021

Authors


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European Federation of Pharmaceutical Industries and Associations More from this funder
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Grant:
Wolfson Merit Award
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Publisher:
Elsevier Publisher's website
Journal:
Journal of Molecular Biology Journal website
Volume:
428
Issue:
22
Pages:
4528-4543
Publication date:
2016-09-05
Acceptance date:
2016-09-26
DOI:
EISSN:
1089-8638
ISSN:
0022-2836
Pubs id:
pubs:699010
URN:
uri:63102083-d209-47a1-a275-a04edeea4a3f
UUID:
uuid:63102083-d209-47a1-a275-a04edeea4a3f
Local pid:
pubs:699010

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