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Nanoscale mapping of newly-synthesised phospholipid molecules in a biological cell using tip-enhanced Raman spectroscopy

Abstract:

Nanoscale chemical mapping of newly-synthesised phospholipid molecules inside a mammalian cell is demonstrated using tip-enhanced Raman spectroscopy (TERS) for the first time using mouse pre-adipocyte cells as a model system. Newly-synthesised membrane phospholipid distribution within a pre-adipocyte cell is mapped with <20 nm spatial resolution, overcoming the diffraction limit of confocal Raman spectroscopy via plasmonic enhancement of Raman signals at a TERS tip-apex.

Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1039/c6cc10226c

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Oxford college:
Lincoln College
Role:
Author
More from this funder
Name:
Biotechnology & Biological Sciences Research Council
Grant:
BB/L002159/1
More from this funder
Name:
UK Department for Business, Energy and Industrial Strategy
Publisher:
Royal Society of Chemistry
Journal:
Chemical Communications More from this journal
Volume:
53
Pages:
2451-2454
Publication date:
2017-02-01
Acceptance date:
2017-01-30
DOI:
EISSN:
1364-548X
ISSN:
1359-7345
Pubs id:
pubs:811772
UUID:
uuid:62fb90c3-4b00-43fc-846d-a50eade06d7f
Local pid:
pubs:811772
Source identifiers:
811772
Deposit date:
2017-12-19

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